GSK126 - EZH2 Methyltransferase Inhibitor. CAS# 1346574-57-9 size:2mg solid Epub 2008 Jul 1
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GSK126 - EZH2 Methyltransferase Inhibitor. CAS# 1346574-57-9 size:2mg solid Epub 2008 Jul 1GSK126, CAS No. 1346574 57 9, is a highly potent and selective small molecule inhibitor of histone methyltransferase EZH2. It potently inhibits both wild type and mutant EZH2 methyltransferase activity with similar potencies (Kiapp 0. 53 nM), independent of substrate used, and is competitive with S adenosylmethionine (SAM) and non competitive with peptide substrates. GSK126 is highly selective against other methyltransferases and multiple other
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