RJR-2403 (oxalate) Size:Solid 2 mg InChi: InChI=1S/C44H51ClN10O9S/c1-28(2)65(61
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RJR-2403 (oxalate) Size:Solid 2 mg InChi: InChI=1S/C44H51ClN10O9S/c1-28(2)65(61Metanicotine, also known as RJR 2403 and TC 2403, is a neuronal nicotinic receptor agonist, showing high selectivity for the 42 subtype. Metanicotine has high affinity to rat brain cortex (Ki = 26 + 3 nM). Metanicotine is comparable to nicotine in activating rat thalamic synaptosomes (EC50 = 732 + 155 nM and Emax = 91 + 8% for RJR 2403; EC50 = 591 + 120 nM and Emax = 100 + 25% for nicotine) . Chronic administration of RJR 2403 in combination with low
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